Nitric oxide plays important roles in a wide variety of physiological processes, including neurotransmission, immune response, blood pressure control, and inhibition of tumor growth. For the purpose of controlling the physiological processes, compounds that selectively release nitric oxide have attracted considerable interest. Among them, nitrosyl ruthenium complexes have been proposed as attractive photodynamic therapeutic agents in biomedicine and in tumor treatment.
This research aims at developing nitrosyl ruthenium complexes which absorb long wavelength visible light to release NO with high quantum yield and are dissolved in water. We describe our progress in designing photoactive ruthenium nitrosyl with schiff base ligands and the properties of the photo-activated NO-releasing of the complexes monitored by UV-VIS, EPR, X-ray crystallography and IR spectroscopy.