Molecular Biomimetics for Drug Development & Energy Conversion
Department of Emerging Materials Science, DGIST, Daegu 42988, Korea
Enzymes, responsible for thousands of metabolic processes that sustain life, are macromolecular biological catalysts. Molecular biomimetics is an emerging area where hybrid technologies are developed by using the tools of synthetic chemistry, molecular biology and nanotechnology. In this talk, we will present our recent results on the molecular biomimetics for metal-O2 complexes mimicking the active site of O2 activating enzymes. The metal ions and the ring size of the supporting ligands are found to be important factors that control the geometric and electronic structures of the metal-O2 complexes (i.e., end-on metal-superoxo vs. side-on metal-peroxo). Reactivity studies performed with the metal-superoxo and -peroxo complexes reveal that the former is capable of conducting electrophilic reactions (e.g., oxygen atom transfer and C-H bond activation of organic substrates), whereas the latter is an active oxidant in nucleophilic reactions (e.g., aldehyde deformylation). Finally, we are going to introduce our ongoing research at DGIST on molecular biomimetics for medicinal applications and small molecule activation related on the energy conversion.