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Synthesis of SCF3-containing isoxazolines and pyrazolines

Bora Kim and Changwoo Cho*

경북대학교 화학과
Isoxazolines and pyrazolines are important classes of heterocycles found in natural products, pharmaceuticals and agrochemicals showing various biological acivities.
In addition, the trifluoromethylthio (SCF3) group is an increasingly important substituent in pharmaceuticals and agrochemicals due to its extremely high lipophilicity that is able to enhance the transmembrane permeation of SCF3-containing molecules.
Therefore, owing to the importance of the SCF3 group, the introduction of the SCF3 group into bioactive compounds has attracted much attention in recent years.
Here, the synthesis of SCF3-containing isoxazolines and pyrazolines will be presented.
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