유제연

제목: Trifluoromethylthiolation at α-position of α,β-Unsaturated Carbonyl Compounds

발표자: Jeyeon Yoo
내용: In recent years, the trifluoromethylthio (SCF3) group has attracted much attention due to its strong electron-withdrawing effect and extremely high lipophilicity. These properties of the SCF3 group can enhance the transmembrane permeation of SCF3-containing organic molecules, that is of great interest to the field of pharmaceuticals and agrochemicals. In addition, α,β-unsaturated carbonyl compounds are important substrates used in many organic reactions, such as cycloadditions, conjugate additions and cascade reactions. Therefore, the incorporation of the SCF3 group into α,β-unsaturated carbonyl compounds is important in that it is capable of synthesizing a variety of bioactive compounds having increased bioavailability. Here, α-trifluoromethylthiolation of α,β-unsaturated carbonyl compounds will be presented.
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