Synthesis of water-soluble Ruthenium Nitrosyl Complexes with Schiff base ligand
Minyeong Kim, Hong-In Lee
Department of Chemistry, Kyungpook National University, Daegu 702-701, Korea
Nitric oxide plays important roles in a wide variety of physiological processes, including neurotransmission, immune response, blood pressure control, and inhibition of tumor growth. For the purpose of controlling the physiological processes, compounds that selectively release nitric oxide have attracted considerable interest. Among them, ruthenium nitrosyl complexes have been proposed as a photodynamic therapeutic agents in biomedicine and in tumor treatment.
Previously, we researched ruthenium nitrosyl complex with salophen ligand, [Ru(Ⅲ)(NO)(salophen)Cl]. This research aims at developing ruthenium nitrosyl complexes which absorb long wavelength visible light to release NO and are dissolved in water. We introduced new ligands with hydroxyl group on the positions of ortho, meta and para of the salophen ligand in order to increase the solubility in water. In this study, we show the NO-releasing properties of the complexes monitored by UV-VIS, IR spectroscopy and EPR.