허규성

Improvement of chiral separation of racemic analytes by NMR spectroscopy and high performance liquid chromatography

Kyu Sung Heo1, Jae Jeong Ryoo2*
1 Department of Chemistry, 2 Department of Chemistry Education, Kyungpook National University, Daegu, Korea 702-701, E-mail: jjryoo@knu.ac.kr
N-3,5-dinitrobenzoyl-(R)-phenylglycinol, (R)-phenylglycine, (S)-leucinol, (S)-leucine and its silylation product were used as an HPLC chiral stationary phase(CSP 1) for the resolution of racemic analytes including 2,2,2-trifluoro-1-(9-anthryl)ethanol(A).1 Due to low selectivity(=1.16) of A on CSP 1, determination of optical purity of A could not be conformed correctly. In this study, we determined the optical purity of A and some chiral compounds using NMR spectroscopy and HPLC. The new CSP for HPLC application was synthesized by using Calixarene and optimized the combination of existing chiral selectors. CSP and Chiral selectors used for HPLC and NMR spectroscopy are shown below..
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1. Jae Jeong Ryoo. et al. Chirality 28, 186–191 (2016)
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